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The Effect of Prehospital Combination of Epinephrine, Vasopressin, and Steroid in OHCA

RecruitingNAAges 18 Years - anyAllNational Taiwan University Hospital
NCT06203847 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This project is a randomized controlled clinical research design, The hypothesis P-I-C-O of the study is: For adult patients in the Taipei City and New Taipei City communities who have suffered sudden non-traumatic death and have been resuscitated by advanced paramedics, the intervention group that receives combined drug treatment (epinephrine, vasopressin, methylprednisolone) has a better rate of sustained recovery of spontaneous circulation (ROSC) (primary outcome) and long-term survival status (secondary outcomes) compared to the control group that receives single drug treatment (epinephrine).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients (aged \>= 18 ) * Out-of-hospital cardiac arrest in the studied regions * Treated by paramedics authorized and capable of giving prehospital medication Exclusion Criteria: * OHCA with traumatic etiology * Obvious signs of death like decapitation, rigor mortis, livor mortis, decomposition, etc. * DNR (Do Not Resuscitation) or termination of resuscitation requested by the family * Patients with known or suspected pregnancy * No vascular access was established before hospital arrival * ROSC before the administrated medication * No patient contact (cancelled ambulance call or the patient was transported to the hospital before the arrival of trial-trained paramedics) * Received epinephrine prior to the arrival of trial-trained paramedics
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What it tests

  • Combination group
  • Standard group
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Where

1 site
National Taiwan University Hospital
Taipei, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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