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Liver Steatosis in Pediatric CD Patients

Recruitingn/aAges 1 Year - 14 YearsAllUniversity of Palermo
NCT06206616 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Celiac disease (CD) is an autoimmune enteropathy triggered by the intake of gluten, characterized by a genetic predisposition. Although, CD is often associated with malabsorption symptoms, a growing number of affected subjects are overweight or frankly obese. One of the conditions that is most frequently detected in pauci/asymptomatic subjects is an increase in transaminases, which often regresses completely after the start of GFD. More recently, a specific liver disorder has shown a certain relevance in adult patients suffering from CD, so much so that the European Society for the Study of Coeliac Disease (ESsCD) has cited it among the possible comorbidities which should be screened in CD subjects: Non-Alcoholic Fatty Liver Disease (NAFLD). In adults, a non-random association between CD and NAFLD has been demonstrated, showing a CD prevalence rate of 2-14% among patients with NAFLD. F

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \>1 and \<14 years * Celiac Disease diagnosis according European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) criteria Exclusion Criteria: * age \<1 and \>14 years; * self-exclusion of gluten/wheat from the diet and refusal to reintroduce it, for diagnostic purposes, before entering the study; * bacterial and/or parasitic infections; * diagnosis of chronic inflammatory intestinal diseases and other organic pathologies affecting the digestive system (for example, serious liver diseases), nervous system diseases, immunological deficits and impairments that limit physical activity; * diagnosis of cancer * patients undergoing chemotherapy and/or radiotherapy.
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What it tests

  • Gluten-free diet
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Where

2 sites
Gastroenterological Paediatrics, Children's Hospital "G. Di Cristina"
Palermo, Italy
General Pediatrics Unit, Children's Hospital "G. Di Cristina"
Palermo, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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