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Bronchoscopic Levofloxacin, Gentamicin, or Sham for Acute Exacerbation of Bronchiectasis

RecruitingPhase 4Ages 18 Years - anyAllAssiut University
NCT06209047 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Randomized single-center trial evaluating whether bronchoscopic instillation of levofloxacin or gentamicin improves outcomes compared to a sham bronchoscopic procedure in adult ICU patients with non-cystic fibrosis bronchiectasis requiring invasive mechanical ventilation. The primary outcome is a ranked composite of in-hospital mortality and time to ventilator liberation. Safety and procedural adverse events are closely monitored.

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📋 Eligibility rules (as published)
Inclusion Criteria: * patients with bronchiectasis confirmed by high-resolution CT chest(HRCT) * patients with acute exacerbation of bronchiectasis who need antibiotic treatment at the hospital due to exacerbation * mechanically ventilated patients in the respiratory ICU * Age more than or equal to 18 years Exclusion Criteria: * patients with active pulmonary tuberculosis * patients with allergic bronchopulmonary aspergillosis * patients who underwent interventional bronchoscopy for hemoptysis * age less than 18 years
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What it tests

  • Local instillation of gentamicin and Budesonide
  • Local instillation of Levofloxacin and Budesonide
  • Bronchoscopic mechanical secretion suction and lavage
  • Sham Bronchoscopy
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Where

1 site
Assiut university hospitals
Asyut, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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