🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Cognitive Impairment in Drug-resistant and Drug-responsive Focal Cryptogenic Epilepsy

Recruitingn/aAges 18 Years - 60 YearsAllIRCCS San Raffaele
NCT06210022 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

This is a national monocentric (San Raffaele Hospital - OSR, Via Olgettina, 60, 20132 Milan, Italy) observational low-risk-intervention study, prospective and multiparametric (clinical, EEG, neuropsychological evaluations) study. Patients with a diagnosis of DRE and DSE will be screened to evaluate their eligibility. They will undergo clinical and cognitive assessments in addition to 32channel EEG at baseline (T0). DRE patients will also undergo clinical and cognitive assessments, and 32-channel EEG at 6 months (T1), and 12 months (T2). Patients newly diagnosed with focal cryptogenic epilepsy (NDE) will undergo clinical and cognitive assessments, and 32-channel EEG at baseline (T0), at 6 months (T1), and 12 months (T2). High-definition EEG will be performed to investigate patterns of cortical sources and functional connectivity alteration specific to DRE and DSE and to explore their pr

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Inclusion criteria for all study subjects: * monolingual native Italian speakers; * age between 18-60 years; * normal or corrected-to-normal visual acuity; * oral and written informed consent to study participation. * if assuming psychotropic drugs (i.e., benzodiazepines, antipsychotics, antidepressants), they should be at stable dosage for more than 4 weeks. * Inclusion criteria for DRE patients: * diagnosis of focal cryptogenic epilepsy; * previous failure of at least 2 anti-seizure medication (ASM at adequate dose; * at least 3 seizures in the last 2 months; • available brain MRI (\<5 years). * Inclusion criteria for DSE patients: * diagnosis of focal cryptogenic epilepsy; * seizure control obtained after not more than 2 ASM; * seizure freedom for at least 6 months; * available brain MRI (\<5 years). * Inclusion criteria for NDE patients: * new diagnosis of focal cryptogenic epilepsy (\<3 months) * not more than 1 ASM tested * available brain MRI (\<3 months) Exclusion Criteria: * Age\> 60 years; * Documented developmental delay; * Evidence of focal abnormalities at neuroimaging (except of hippocampal sclerosis); * Neurological degenerative conditions; * history of other systemic (including systemic neoplasms in the last 3 years and abnormal hepatorenal functions), neurologic, psychiatric diseases, head injury, cardiovascular events, and cerebrovascular alterations; * alcohol and/or psychotropic drugs abuse
💊

What it tests

  • Neuropsychological Assessment
📍

Where

1 site
IRCCS San Raffaele
Milan, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy