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Multiparametric MRI in a Prospective Cohort of Living Kidney Donors, Recipients, and Healthy Controls: Correlations With Markers of Renal Function, Fibrosis and Ageing

Recruitingn/aAges 18 Years - 80 YearsAllPatrick Schjelderup
NCT06210555 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Development of renal fibrosis is the irreversible culmination of various renal diseases and independently predicts adverse outcomes. Currently renal fibrosis can only be diagnosed by performing a renal biopsy. The procedure is invasive and is limited by sampling bias. In recent years there has been a significant development in magnetic resonance imaging (MRI) based techniques. MRI can provide highly detailed anatomical images. Other MRI measures allow quantitative measurements of perfusion, oxygenation, tissue stiffness and diffusion of water molecules within tissue. The combination of several MRI techniques sensitive to different biophysical tissue properties in a single scan session is referred to as multiparametric MRI (mpMRI). Emerging evidence suggests that mpMRI could represent a method for indirect characterization of renal microstructure and extent of fibrosis. So far, studies

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📋 Eligibility rules (as published)
Living kidney donors and transplant recipients: Inclusion Criteria: * Approved as a living kidney donor or recipient of a kidney from a living donor. * Able to cooperate to an MRI examination Exclusion Criteria: * Contraindications to MRI due to incompatible foreign objects. * Severe claustrophobia Healthy controls: Inclusion Criteria: * Office BP \< 140/90 mmHg. (use of 1 antihypertensive drug allowed) * Normal eGFR. (CKD-EPI) * Urine albumin-to-creatinine ratio \< 30 mg/g. * Dipstick negative for hematuria and proteinuria. * Able to cooperate to an MRI examination. Exclusion Criteria: * Contraindications to MRI due to incompatible foreign objects. * Severe claustrophobia. * Pregnancy. * Condition(s) that would exclude living kidney donation.
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What it tests

  • Renal transplantation
  • Living kidney donation
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Where

2 sites
Department of Renal Medicine, Aarhus University Hospital
Aarhus, Denmark
Department of Nephrology, Aalborg University Hospital
Aalborg, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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