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Getting Under the Skin of the Menopausal Hot Flush

Recruitingn/aAges 18 Years - 60 YearsFemaleLiverpool John Moores University
NCT06222073 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this research is to 1) test how the skin blood vessels and sweat glands function in women who experience hot flushes by using skin microdialysis to deliver small amounts of substances to the skin that cause increased skin blood flow and sweating, and 2) examine the structure of the skin blood vessels and sweat glands in the skin of women who experience hot flushes by taking a very small skin biopsy. Any changes in the function or structure of the skin blood vessels or sweat glands in women with hot flushes would increase our understanding of what causes hot flushes and help to design effective treatments.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged \>45 years for the postmenopausal cohort and aged 18-30 years for the premenopausal cohort * Female * Amenorrhoeic for \>6 months (postmenopausal criteria) * \>4 hot flushes per day (symptomatic postmenopausal criteria) * Eumenorrhoeic with regular menstrual cycles (premenopausal criteria) * Healthy * Non-smoker * BMI 18-30 kg/m2 * No history of cardiovascular or respiratory disease * No history of metabolic disease e.g. type II diabetes * Drink \<14 units of alcohol per week * Not taking any medication or treatments to alleviate hot flushes Exclusion Criteria: * Aged \< 18 years or 31-44 years * Male * Smokers * Medical history of cardiovascular/respiratory disease * Medical history of metabolic disease e.g. type II diabetes * Drink \>15 units of alcohol per week * On medication or treatments to alleviate hot flushes or have taken such medication/treatment within the previous 6 months * BMI of \<18 or \>30 kg/m2 * Vaccination (\<1 week) due to induced systemic inflammatory reaction * Local forearm infection * Allergy to local anaesthetic/Marcain/amide-group anaesthetics * Pregnant
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What it tests

  • Not listed
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Where

1 site
Liverpool John Moores University
Liverpool, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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