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Oxytocin and Reward Processing in Women

RecruitingNAAges 18 Years - 40 YearsFemaleInternational Research Training Group 2804
NCT06222749 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Oxytocin is a hypothalamic neuropeptide that is best known for its peripheral physiological effects in the female organism i.e., uterine contractions during birth. The neuropeptide furthermore affects reward processing and metabolic functions such as eating behavior and body weight. Oxytocin receptors are present in brain regions associated with the processing of rewards, e.g., ventral tegmental area (VTA), nucleus accumbens (NAcc) and nucleus stria terminalis. Previous studies indicate that oxytocin interacts with sex hormones such as estradiol in a sex-specific manner. Despite known sex differences in oxytocin function, most studies i.e., on the metabolic effects of oxytocin in humans have so far focused on young, healthy men. Intranasal oxytocin administration has emerged as a method to experimentally investigate central nervous effects of oxytocin in the absence of relevant side ef

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📋 Eligibility rules (as published)
Inclusion Criteria: * Body-mass index (BMI): 18-28 kg/m2 * Sex: female (since birth) * Normal or corrected vision * Natural menstrual cycle (NC) or intake of hormonal oral contraceptives (OC) * NC: No hormonal contraception for at least 6 months; regular menstrual cycle (between 25 and 31 days) prior to participation * OC: No hormonal contraception for at least 4 months, regular intake of OC pill Exclusion Criteria: * No German language fluency (due to German language test content) * Smoking * Medication taken within the last 6 weeks (except for OCs in the respective group) * Current neurological or psychiatric disease (anamnestic survey) * Current medical problems such as hormonal, metabolic, or chronic diseases (e.g., severe hypertension, diabetes, dysfunctions of the thyroid, or congestive heart failure) * Pregnancy, delivery and lactation (current and within the last year; anamnestic survey, current pregnancy test) * Premenstrual dysphoric disorder (PMDD), endometriosis or polycystic ovary syndrome (PCOS) * Shift work * NC: Any kind of hormonal treatment or contraception * OC: Any kind of hormonal treatment or contraception (except OCs) * Contraindication for MRI: * Non-removable metal objects on or in the body * Tattoos (if MRI-incompatible according to expert guidelines) * Pathological hearing or increased sensitivity to loud noise * Claustrophobia * Operation less than three months ago * Neurological disease or injury * Moderate or severe head injury * Intake of antidepressants or neuroleptics * Restricted vision
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What it tests

  • Intranasal oxytocin administration
  • Intranasal placebo administration
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Where

1 site
University of Tuebingen; Department of Psychiatry & Psychotherapy; Institute of Medical Psychology and Behavioural Neurobiology
Tübingen, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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