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Weekly Isotretinoin vs Tetracycline for Moderate Acne

RecruitingEARLY Phase 1Ages 12 Years - anyAllMedical University of South Carolina
NCT06225570 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In the effort to find better treatments for Moderate Acne, which often relies on long-term antibiotic use, researchers are exploring alternative options. While Isotretinoin, a Vitamin A derivative, is highly effective for severe acne, its side effects limit its use for milder cases. A recent study from our institution investigated a new approach: weekly Isotretinoin dosing. The results were promising, with acne improvement and no major side effects. This suggests that weekly Isotretinoin could be a successful alternative for moderate acne in both males and females. To validate these findings, investigators propose a randomized controlled trial comparing weekly Isotretinoin to daily Doxycycline over four months. This study could confirm the safety and effectiveness of weekly Isotretinoin, as well as shed light on patient satisfaction, and long-term results compared to standard antibiotics

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📋 Eligibility rules (as published)
Inclusion Criteria: \- Male and Female patients, 12 years and older with a diagnosis of Moderate Acne Vulgaris Exclusion Criteria: * Patients who are at baseline on long-term Tetracycline antibiotics, long-term Trimethoprim-Sulfamethoxazole, or on Spironolactone for any reason * Patients who have taken Isotretinoin in the past 6 months * Patients with hypersensitivity to Isotretinoin or to any of its components * Females who are pregnant, likely to become pregnant, or will be breast-feeding during the study period * Patients with a history of major depression, mania, or psychosis with an active episode during the past year including current psychotic symptoms and/or current suicidal ideation * Adult patients with cognitive impairment * Patients with baseline kidney or liver disease * Patients with baseline hypertriglyceridemia * Patients with history of or current pseudotumor cerebri * Patients with any clinically significant unstable medical condition which could pose a risk to the safety of the patient * Inability or unwillingness of subject or legal guardian/representative to give informed consent
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What it tests

  • Isotretinoin
  • Tetracycline
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Where

1 site
Medical University of South Carolina
Charleston, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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