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Threonine Requirement in Adults >60 Years of Age

RecruitingNAAges 60 Years - 90 YearsAllThe Hospital for Sick Children
NCT06225648 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Threonine is an essential amino acid and must be obtained from the diet. The body's capacity to maintain adequate mucin synthesis is directly related to the bioavailability of certain amino acids, including threonine, serine and proline (1). Moreover, the rate of mucin synthesis has been demonstrated to be directly related to the availability of dietary threonine in healthy rats (2) and piglets (3,4). Intestinal inflammation is known to increase gastrointestinal threonine uptake and mucin synthesis in enterally fed minipigs (5). Additionally, in animals, mucin function/barrier has been shown to decline with age, leaving them more susceptible to bacterial penetration. Thus, with advancing age (6), a higher dietary supply of threonine may be needed for maintaining intestinal mucosal health. Despite this, the current threonine requirement is based on studies conducted exclusively in young a

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📋 Eligibility rules (as published)
Inclusion Criteria: * Consent provided * Aged 60 to 90 years old * In good general health as evidenced by medical history, physical health and blood draw * Fasting blood glucose, hemoglobin A1c (HbA1c), urea, creatinine * Willingness to participate in the study. * BMI \<30 kg/m2. Exclusion Criteria: * Presence of chronic disease and/or acute illness known to affect protein/amino acid metabolism (e.g. HIV, diabetes, cancer, liver or kidney disease, acute cold or flu) * Taking medications known to affect protein/AA metabolism (e.g. steroids) * Inability to tolerate the diet (i.e. allergy) * Significant weight loss during the past month or consumption of weight reducing diets. * Significant caffeine consumption (\>2 cups per day) * Significant consumption of alcohol (\>1 drink per day i.e. 1 beer or ½ glass of wine). * Unwilling to have blood drawn from a venous access, or using a ventilated hood indirect calorimeter for the purposes of the study.
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What it tests

  • threonine
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Where

1 site
The Hospital for Sick Children
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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