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Magnetic Resonance Imaging and Ultrasound Comparison With Load Evaluation

Recruitingn/aAges 18 Years - 70 YearsAllRadboud University Medical Center
NCT06227182 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Facioscapulohumeral dystrophy (FSHD) is one of the most common hereditary neuromuscular disorders (NMD), with an estimated prevalence of 2000 patients in the Netherlands. Magnetic resonance imaging (MRI) and muscle ultrasound have contributed to an enhanced understanding of the pathophysiology of Facioscapulohumeral Muscular Dystrophy (FSHD). Previously, our group demonstrated the potential presence of an intermediate factor between muscle fiber loss and clinical weakness in FSHD. The influence of disrupted muscle architecture in FSHD on muscle contractile efficiency is a likely candidate for this factor, and remains relatively unexplored. In this study, we aim to assess the use of ultrasound-defined contractile performance, in comparison with current measures including structural MRI, for monitoring disease progression in FSHD.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age between 18 and 70 years. * Informed consent is given by the participant. * Ability to read and understand written and spoken instruction in Dutch. * Willingness and ability to understand nature and content of the study Exclusion Criteria: * BMI ≥ 35 * Other diseases that could diffusely affect muscle integrity or disturb the imaging appearance beyond that what can be extrapolated. * Wheelchair dependence * Pregnancy * Stage II: Any contra-indications for MRI, including: * Claustrophobia * Pacemakers and defibrillators * Nerve stimulators * Intracranial clips * Intraorbital or intraocular metallic fragments * Cochlear implants and ferromagnetic implants (e.g. implant for scoliosis) * Inability to lie supine for 60 minutes * Necessity of (continuous) daytime ventilation * Scoliosis surgery
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What it tests

  • Muscle ultrasound with surface electromyography and dynamometry
  • MRI scan
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Where

1 site
Radboud university medical center
Nijmegen, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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