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Effect of a Furosemide Stress Test-Guided Strategy on Liberation From Continuous Renal Replacement Therapy in Critically Ill Patients With Acute Kidney Injury

RecruitingPhase 4Ages 20 Years - anyAllChiang Mai University
NCT06229990 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Currently, continuous renal replacement therapy (CRRT) is the main modality for renal support in critically ill patients with hemodynamic instability. Most studies have investigated the timing of RRT initiation. However, prolonged CRRT demonstrated the association of many unexpected events, such as catheter-related complications, catheter-related blood stream infection, hypotension, hypothermia, tachycardia, and atrial fibrillation. Up to now, there is a lack of evidence regarding the timing of withholding CRRT. The furosemide stress test (FST) is a tool that is easy to use and has more availability. The investigators aimed to apply FST to evaluate renal recovery compared with standard treatment in critically ill patients undergoing CRRT.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult 20 year of age or older * Acute kidney injury (AKI) stage 3 according to Kidney Disease Improving Global Outcomes (KDIGO) classification with oliguria (urine \<400 ml/day) * Initiate CRRT in ICU (medical ICU, surgical ICU, cardiac care unit) for at least 48 hours (time for initiation and modality of CRRT can adjust by clinician) Exclusion Criteria: * Use any inotropic drug (norepinephrine, epinephrine, dopamine, dobutamine) * Blood urea nitrogen (BUN) \>80 mg/dL * Serum K \<3.5 or \>5 mmol/L * Arterial potential of Hydrogen (pH) \<7.3 * Serum bicarbonate (HCO3) \<15 mmol/L * Urine volume \<400 or \>2,100 mL/day * Urine creatinine clearance (CrCl) at 6 hours \>20 mL/min * Previous chronic kidney disease (CKD) stage 5 or estimated glomerular filtration rate (eGFR) \<15 mL/min/1.73 m2 * Previous RRT within 14 days * Kidney transplantation * Obstructive etiology for AKI * Toxin/drug that necessitates RRT * Allergy to furosemide * Moribund with expected death within 24 hours * Pregnancy
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What it tests

  • Furosemide Injection
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Where

1 site
Chiang Mai University
Chiang Mai, Thailand
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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