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The Effect of Retrograde Autologous Priming on Transfusion Requirements After Cardiac Surgery

RecruitingNAAges 10 Years - 110 YearsAllPopulation Health Research Institute
NCT06230198 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The TheRAPy vanguard trial is a multicentre, multiple period randomized, cluster crossover vanguard trial testing the feasibility of a full-scale trial to evaluate whether a centre-based policy of routine use of RAP versus a policy of crystalloid priming reduces RBC transfusion for patients undergoing cardiac surgery on cardiopulmonary bypass. It will also provide information about key parameters of the TheRAPy full-scale trial.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Hospitals completing \>200 adult cardiac surgical cases a year; (ii) 95% of cardiovascular surgery group (i.e., cardiac anesthesiologists, surgeons, and perfusionists) agree to manage patients under both autologous priming policies as per their randomization schedule for the duration of the trial. * All patients undergoing cardiac surgery on cardiopulmonary bypass at an enrolled site during the trial period will be included in data collection. Exclusion Criteria: * Complete \<=200 cardiac surgical cases. * \<95% of their cardiovascular surgery group agrees to manage patients according to either of the two policies.
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What it tests

  • retrograde autologous priming (RAP)
  • Crystalloid priming
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Where

4 sites
St. Boniface Hospital
Winnipeg, Canada
Hamilton General Hospital
Hamilton, Canada
Montreal Heart Institute
Montreal, Canada
Centre Hospitalier de l&#39;Université de Montréal (CHUM)
Montreal, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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