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Administration Of Calcium Gluconate for The Reduction of Blood Loss During Elective Cesarean Delivery

RecruitingNAAges 18 Years - anyFemaleRambam Health Care Campus
NCT06235749 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Postpartum hemorrhage (PPH) is the leading cause of death related to pregnancy. PPH can lead to blood transfusion, disseminated intravascular coagulation (DIC), hysterectomy, or death. The prophylactic administration of uterotonic agents as part of an active management of the third stage of labor has been proven to reduce rates of PPH. However, even with these treatments, PPH rate is still relatively high, and puts women at risk of heavy bleeding and death. Calcium is a key component in the coagulation cascade and known as factor IV. It has a role in platelet activation, and it is an important co-factor for the activation of factors II and There is a concentration-dependent effect of hypocalcemia on in vitro clot strength in patients at risk of bleeding. Calcium gluconate is the calcium salt of gluconic acid, and it has a relatively strong safety profile. Hypocalcemia is a poor prognos

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📋 Eligibility rules (as published)
Inclusion Criteria: \- Elective Cesarean Delivery, at Gestational age of 35 weeks or more. Exclusion Criteria: * Age younger than 18 years old. * Patients treated with calcium channel blockers. * Chronic renal failure and hyperphosphatemia. * Sarcoidosis. * Hypocalcemia (ionized Ca\<1 mmol/L) or hypercalcemia (ionized Ca\> 1.3 mmol/L) before the surgery. * Any QT abnormalities as evident by ECG before Calcium Gluconate administrations or any known conduction abnormality.
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What it tests

  • Calcium Gluconate 10%
  • sodium chloride 0.9%
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Where

4 sites
Soroka Medical Center
Beersheba, Israel
Shamir Medical Center
Be’er Ya‘aqov, Israel
Rambam Medical Center
Haifa, Israel
Edith Wolfson Medical Center
Holon, Israel
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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