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Validation of Donor Oocytes Semi-automated Vitrification

RecruitingNAAges 18 Years - 38 YearsFemaleUniversity Hospital, Clermont-Ferrand
NCT06238570 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Oocyte vitrification is an effective method of freezing which has been authorized in France since 2011. The arrival of this technique has led to real improvements in the survival rate of oocytes after warming compared to that observed after slow freezing, a method previously applied. Oocytes reheated after vitrification show excellent results in terms of vitality and recovery of cellular functionality. Indeed, the fertilization rates observed after using warmed and fertilized oocytes in Assisted Reproduction Technology (ART) by intracytoplasmic sperm injection (ICSI) are similar to those obtained with fresh oocytes. However, the manual vitrification techniques used until now involve a learning curve and a potential variability of the completion time depending on the operator and the number of oocytes to be vitrified. Oocyte vitrification is a key step to optimize the chances of pregnan

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📋 Eligibility rules (as published)
Inclusion Criteria: * Egg donor * Oocyte puncture for donation * Good quality ovarian reserve (Antral follicle count evaluated by ultrasound: CFA ≥ 7) * Negative serology status (HIV, hepatitis B and C, syphilis, CMV and HTLV) * Absence of symptoms or COVID contact * Absence of genetic contraindication to egg donation * Woman able to give informed consent to participate in research * Woman affiliated to a social security scheme Exclusion Criteria: * Decline to participate * Pregnant and lactating woman * Person under guardianship, curatorship, deprivation of liberty, protection of justice
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What it tests

  • Gavi, Merck® (automated vitrification instrument)
  • Vitrolife system
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Where

1 site
CHU de Clermont-Ferrand
Clermont-Ferrand, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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