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โ† Trials
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Myasthenia Gravis Registry in China

Recruitingn/aAges any - anyAllHuashan Hospital
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In plain words

What the trial is, and whether it could suit you

Myasthenia gravis (MG) is an autoimmune disease caused by dysfunction at the neuromuscular junction, characterized by partial or generalized skeletal muscle weakness and fatigability. The estimated annual incidence rate of MG in China is 0.68/100,000, with a high rate of relapse and poor treatment compliance. This study is a prospective, observational, multi-center patient registry across China. To support standardized management and follow-up of MG patients in China, a Cloud-based MG Patient Management Platform (CN MG Base) was established in September 2023 with the support of the Chinese Rare Diseases Alliance. The platform aims to collect longitudinal clinical data including demographic information, age of onset, medical history, comorbidities, medication usage, treatment responses, and others. It is intended to collect newly registered MG cases each year and follow up with these pati

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Fluctuating weakness in skeletal muscles, such as extraocular, bulbar, limb muscles, etc.. Demonstrating fluctuation and fatigability: Weakness is usually worse in the morning and improves with rest; worsens with sustained activity. * Patients themselves or their guardians can understand and sign the informed consent form. To meet the eligibility criteria, at least one of the following additional criteria must be met: * a. Positive Tensilon test; * b. Decrease in compound muscle action potential by more than 10% with low-frequency repetitive nerve stimulation or widening of the "jitter" (the variability in time of the second action potential relative to the first) on single-fiber electromyography, with or without blocking; * c. Positive antibodies: Serum testing positive for AChR antibodies, MuSK antibodies, or LRP4 antibodies. Exclusion Criteria: * Patients with mental illness who cannot cooperate. * Patients with multiple organ dysfunction or in extremely critical condition, unable to complete relevant medical history collection or evaluation.
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What it tests

  • Not listed
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Where

16 sites
Beijing Hospital
Beijing, China
Xuanwu hospital, Capital medical university
Beijing, China
Peking Union Medical College Hospital
Beijing, China
The First Affiliated Hospital of Chongqing Medical University
Chongqing, China
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, China
The Third Hospital, Sun Yat-sen University
Guangzhou, China
First Affiliated Hospital of Zhengzhou University
Zhengzhou, China
Xiangya hospital, Central south university
Changsha, China

โ€ฆand 8 more on ClinicalTrials.gov.

๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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