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Oscillatory Activity in Basal Ganglia Circuits During Normal and Pathological Movement

RecruitingNAAges 18 Years - 75 YearsAllUniversity Hospital, Bordeaux
NCT06241924 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The expression of hypokinetic and hyperkinetic motor symptoms is accompanied by pathological synchronous oscillations of neuronal activity in this cortico-subcortical network with a wide frequency range. The purpose of this research is to study cortico-subcortical oscillations and their synchronization in two pathologies emblematic of hypokinetic (Parkinson's disease) and hyperkinetic (epilepsies) phenomena using a simple motor task and comparing different situations.

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📋 Eligibility rules (as published)
Inclusion criteria : * Male or Female * Between 18 and 75 years of age * With Parkinson's disease and already operated with implantation of electrodes in the Subthalamic nucleus connected to a PERCEPT (TM) device. * Giving free, informed, written consent signed by the participant and the investigator Or * With drug-resistant epilepsy and benefiting from a phase II pre-surgical assessment with intracerebral electrophysiological exploration by stereo-EEG * With at least one electrode exploring the basal ganglia or the thalamus. * Able to perform the simple motor task * Affiliated or beneficiary of a social security scheme; * Giving free, informed, written consent signed by the participant and the investigator Exclusion criteria: * Be incapable of giving consent personally * Be subject to a legal protection measure or be placed under judicial protection; * Being pregnant or breastfeeding * Present a serious and/or decompensated somatic or psychiatric illness
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What it tests

  • High Resolution Electroencephalogram (EEG-HR)
  • Stereo-electro-encephalography (SEEG)
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Where

1 site
CHU de Bordeaux
Bordeaux, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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