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Effects of Letrozole During the Luteal Phase After Controlled Ovarian Stimulation in Oocyte Donors.

RecruitingPhase 3Ages 18 Years - 34 YearsFemaleIVI Madrid
NCT06244745 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The objective of this trial is to determine whether the use of letrozole during the luteal phase in oocyte donors diminishes the ovarian volume, as well as to evaluate its effect on the duration of the luteal phase, taking into account hormonal and biochemical markers. Two groups will be established with random allocation of patients and 1:1 proportionality, as follows: * Control group: No specific treatment. * Study group: Oral administration of letrozole 5 mg (each capsule is 2.5 mg) once a day for 5 days starting on the night of the follicular puncture.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Hyper-responsiveness to stimulation, defined as the presence of ≥18 follicles of size ≥11 mm (22-24) on the day of the last ultrasound visit prior to ovarian puncture. Exclusion Criteria: * Participation in another clinical study, prior to inclusion in the present study, that could affect the objectives of this study. * Known allergy to letrozole. * Known lactose intolerance.
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What it tests

  • Administration of letrozole
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Where

1 site
IVI-Madrid
Madrid, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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