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โ† Trials
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Evaluating the Functional Status of the Adrenal Glands With [68Ga]Ga-PentixaFor in Hyperaldosteronism and Hypercortisolism

RecruitingPhase 2Ages 18 Years - 120 YearsAllNational Cancer Institute (NCI)
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In plain words

What the trial is, and whether it could suit you

Background: The adrenal glands are 2 small organs that sit on top of each kidney. They release hormones; these are chemicals that control how the body works. Tumors on or outside the adrenal glands are called functional if they release hormones; they are called nonfunctional if they do not. Doctors who treat adrenal tumors need to know which type a person has. Researchers want to find better ways to learn whether an adrenal tumor is functional. Objective: To see if a new radioactive tracer (\[68Ga\]Ga-PentixaFor) can make it easier to identify functional adrenal tumors with positron emission tomography (PET) scans. Eligibility: People aged 18 years and older with 1 or more adrenal tumors. They must have increased levels of the hormones aldosterone or cortisol. They must also be enrolled in at least 1 other related NIH study (protocols 19-DK-0066, 18-CH-0031, or 09-C-0242). Design:

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
* INCLUSION CRITERIA: * Must have any of the following: * one or more adrenal masses on CT and/or MRI and biochemical evidence of excess aldosterone OR --ACTH-independent hypercortisolism, with or without adrenal masses on CT and/or MRI OR * history of ACTH-dependent hypercortisolism (with or without adrenal enlargement) * Co-enrollment in 19-DK-0066, 09-C-0242, 18-CH-0031 or a similar NIH trial. * Age \>=18 years. * ECOG performance status \<= 2. * Women of child-bearing potential (WOCBP) and men must agree to use an effective contraception (barrier, hormonal, intrauterine device \[IUD\], surgical sterilization, abstinence) for two weeks prior to \[68Ga\]Ga-PentixaFor scan and for one week after the \[68Ga\]Ga-PentixaFor scan. * Breastfeeding should be discontinued for one week after the \[68Ga\]Ga-PentixaFor scan. * Men must agree not to donate sperm for one week after the \[68Ga\]Ga-PentixaFor scan. * Participants must be able to understand and willing to sign a written informed consent document. EXCLUSION CRITERIA: * Positive beta-human chorionic gonadotropin (beta-HCG) serum or urine pregnancy test performed in females of childbearing potential at screening. * Uncontrolled intercurrent illness or social situations based on the review of medical history that would limit compliance with study requirements. * Contraindications to having an MRI and CT.
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What it tests

  • [68Ga]Ga-PentixaFor
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Where

1 site
National Institutes of Health Clinical Center
Bethesda, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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