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The Effect of Sex Steroid Replacement Therapy in the Hypogonadism and Transgender Active-Duty Population

Recruitingn/aAges 18 Years - 65 YearsAllWalter Reed National Military Medical Center
NCT06247267 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

It has been known that both estrogen and testosterone are the major sex steroids regulating bone metabolism and other physiological changes in both male and female, respectively. In postmenopausal women, osteoporosis is a major concern secondary to the lack of estrogen. These patients also experience a number of physiological changes that affect their life permanently to include hot flashes, irritability, difficulty concentrating, depression and mental confusion. In hypogonadal men, testosterone deficiency could lead to higher prevalence of depression, osteoporosis, fracture and frailty. Given the new military policy starting to support treatment for gender identity dysphoria military personnel, the number of transgender patients in our Endocrinology clinic has been slowly increasing over the past several months. These patients will require either testosterone replacement therapy or estr

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male and female DoD health care beneficiaries * Ages 18-65 * Diagnosed with primary hypogonadism or transgender treatment for at least 6 months * Under care for gender identity dysphoria * On stable dose of sex steroid hormonal therapy for at least 6 months prior to enrolling * Must be living in the Washington, D.C. area for at least 12 months following enrollment Exclusion Criteria: * Pregnancy, plan for pregnancy in the next 12 months * Cardiac disease, especially coronary artery disease * Malabsorption disorder * Gastrointestinal surgeries * Significant renal or liver dysfunction * Seizure disorders * recent orders to move out of the geographic area * Age less than 18 years old or older than 65 years old * Scheduled for deployment
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What it tests

  • Fortesta
  • Estradiol
  • Fortesta
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Where

1 site
Walter Reed National Military Medical Center
Bethesda, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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