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Continuous Infusion of Norepinephrine vs Phenylephrine During Spinal Anesthesia for Cesarean Section (INPEACE)

RecruitingPhase 4Ages 18 Years - 45 YearsFemaleHassan II University
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to compare norepinephrine and ephedrine in maintaining blood pressure during spinal anaesthesia for elective cesarean delivery. The main questions it aims to answer are: * Do phenylephrine and norepinephrine administered as manually controlled continuous infusion during elective cesarean delivery have different effects on neonatal outcome ? * Do phenylephrine and norepinephrine administered as manually controlled continuous infusion during elective cesarean delivery have different effects on maternal hemodynamics? Participants will receive either phenylephrine or norepinephrine infusion, at the time of performing spinal anesthesia, the infusion rate will be adjusted manually depending on maternal arterial pressure.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Full-term, singleton, pregnant women, nonlaboring. * Scheduled for elective cesarean delivery under spinal anesthesia, * American Society of Anesthesiologists physical status : 1 or 2 * Baseline systolic BP between 90 and 140 mm Hg. Exclusion Criteria: * Known fetal abnormality. * Preexisting or pregnancy-induced hypertension, cardiovascular, cerebrovascular or kidney disease. * Contraindication to spinal anesthesia. * Peripartum hemorrhage. * Body mass index above 40 kg/m2.
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What it tests

  • Continuous infusion of Norepinephrine
  • Continuous infusion of Phenylephrine
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Where

2 sites
University hospital Hassan II
Fes, Morocco
University hospital Hassan II
Fes, Morocco
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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