SAVE- Oral Antibiotics for Treatment of Vertebral Osteomyelitis

Inclusion Criteria: 1. Age ≥18 years 2. Diagnosed with PVO by a physician based on clinical symptoms and findings consistent with PVO in combination with diagnostic imaging (MRI, PET/CT or PET/MRI) 3. The physician responsible for the patient decides to treat the patient for PVO 4. At time of randomization CRP has decreased to \< 75% of peak value or to \< 20 mg/l 5. At the time of randomization patient has received maximum 7 days of appropriate IV AB for PVO - Exclusion Criteria: 1. Previous episodes of PVO within the past 24 months 2. Spinal implants inserted prior to current episode of PVO 3. Hypersensitivity to an AB intended for use in the patient and no alternative drugs available. 4. Oral ABs not possible due to suspicion of reduced absorption 5. Oral Abs not possible due to verified or expected bacterial susceptibility or due to expected toxicity of available regimen 6. Identification of fungus, mold, TB, Brucella, Actinomyces, Nocardia and P. aeruginosa as etiology 7. Severe immunocompromise defined as primary immunodeficiencies, uncontrolled HIV/AIDS, organ transplant recipients, hematological malignancies, patients undergoing biological therapy or chemotherapy and patients treated with prednisolone \>=20 mg daily \>14 days 8. Verified or expected reduced compliance (for example iv drug use) 9. Pregnancy 10. Breastfeeding 11. Women of childbearing potential, who at the time of inclusion are not using and/or who will not use an effective anticonception method during the treatment period. 12. Patients not capable of providing informed consent at time of screening for inclusion 13. Diagnosed or suspected concomitant or unrelated infections necessitating IV AB therapy beyond 7 days of duration at the time of randomization -