Plan Development for Giving Teclistamab in the Outpatient Setting

Multiple Myeloma Patients to Receive Outpatient Teclistamab (Part 1): Inclusion Criteria: 1. Eligible for teclistamab treatment as per Health Canada approved indication: 1. Age 18 and greater 2. Relapsed or refractory multiple myeloma 3. Received at least 3 prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent and an anti-CD38 monoclonal antibody 4. Demonstrated disease progression on the last therapy 2. For Cohorts 1 and 2, participants must agree to receive treatment at Princess Margaret Cancer Centre. For Cohort 3, participants must agree to receive treatment at Stronach Regional Cancer Centre. 3. Must sign the informed consent form (or their legally acceptable representative must sign) indicating that the participant understands the purpose of, and procedures required for the study and is willing to participate in the study. Consent is to be obtained prior to the initiation of any study-related tests or procedures that are not part of standard of care for the patient's disease. 4. Have one or more caregivers meeting study criteria. 5. Have clinical laboratory values meeting study criteria. 6. Rockwood Clinical Frailty Scale - threshold score ≤ 5 7. A woman of childbearing potential must have a negative highly-sensitive serum pregnancy test at screening and must agree to: 1. Practicing true abstinence; or 2. Have a sole partner who is vasectomized; or 3. Practicing ≥1 highly-effective, user-independent method of contraception. 8. A woman must agree not to donate eggs (ova, oocytes) or freeze for future use, for the purposes of assisted reproduction during the study. Upon study end, female participants must agree to continue with product monograph guidelines with ongoing teclistamab off-study. 9. A man must wear a condom (with or without spermicidal foam/gel/film/cream/suppository) when engaging in any activity that allows for passage of ejaculate to another person during the study, and thereafter to continue with product monograph guidelines. If a female partner is of childbearing potential, she must also be practicing a highly effective method of contraception. 10. A male participant must agree not to donate sperm for the purpose of reproduction during the study, and thereafter to follow product monograph guidelines with ongoing teclistamab off-study. Exclusion Criteria: 1. Contraindications or life-threatening allergies, hypersensitivity, or intolerance to any study drug or its excipients. 2. Prior or concurrent exposure to any of the following: 1. Teclistamab or any anti-BCMA therapy 2. Other myeloma therapy (standard of care or investigational) including corticosteroids, within 3 days of first step-up dose of teclistamab 3. Toxicities from previous anticancer therapies that have not resolved to baseline levels or to Grade 1 or less except for alopecia or peripheral neuropathy 4. High risk disease features including: 1. Central nervous system (CNS) involvement with myeloma 2. Extramedullary disease (≥1 soft tissue plasmacytoma not associated with bone) 3. Circulating plasma cells (plasma cell leukemia) 4. Rapidly progressive disease, as per investigator assessment 5. Concurrent disorders, including: e. Light chain amyloidosis f. Second malignancy requiring active therapy, exceptions including prostate cancer receiving androgen deprivation therapy or adequately treated breast cancer carcinoma on anti-hormonal agents and considered to have a very low risk of recurrence g. Underlying neurologic dysfunction (history of seizure, Cerebrovascular Accident (CVA) or Transient ischemic attack (TIA), intracranial hemorrhage, dementia or other cognitive impairment) h. Hepatitis B infection (HBV-DNA positive). Patients with HepBsAg (Surface antigen of Hepatitis B virus) or HepBcAb (Hepatitis B viral protein) positive are allowed on study, only if on antiviral prophylaxis and HBV-DNA viral load is undetectable. i. Active infection requiring anti-infective therapy (prophylactic antibiotics are allowed). Cytomegalovirus (CMV) IgG (Immunoglobulin G) positivity allowed, but must be CMV PCR (Polymerase Chain Reaction) negative. j. Underlying coagulopathy that may increase the risk of bleeding in the setting of cytopenia. 6. Presence of the following cardiac conditions: 1. New York Heart Association stage III or IV congestive heart failure 2. Myocardial infarction or coronary artery bypass graft ≤6 months prior to randomization 3. History of clinically significant ventricular arrhythmia or unexplained syncope, not believed to be vasovagal in nature or due to dehydration 4. History of severe non-ischemic cardiomyopathy 7. Major surgery within 2 weeks prior to the start of administration of study treatment (kyphoplasty or vertebroplasty are not considered major surgery). 8. Concurrent medical or psychiatric condition or disease that is likely to interfere with study procedures or results, or that in the opinion of the investigator would constitute a hazard for participating in this study, such as: 1. Uncontrolled diabetes 2. Acute diffuse infiltrative pulmonary disease 3. Evidence of active systemic viral, fungal, or bacterial infection, requiring systemic antimicrobial therapy 4. History of autoimmune disease with the exception of vitiligo, type I diabetes, and prior autoimmune thyroiditis that is currently euthyroid based on clinical symptoms and laboratory testing 5. Disabling psychiatric conditions (e.g., alcohol or drug abuse), severe dementia, or altered mental status 6. Other comorbidities felt by treating physician to require hospitalization for teclistamab step-up dosing, such as poorly controlled pain despite use of narcotics, multiple concurrent comorbidities (diabetes, advanced age, cardiac disease) 7. Any other issue that would impair the ability of the participant to receive or tolerate the planned treatment at the investigational site, to understand informed consent