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โ† Trials
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pBFS Guided rTMS Over Cognitive Control Network for ASD

RecruitingNAAges 6 Years - 30 YearsAllChangping Laboratory
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In plain words

What the trial is, and whether it could suit you

The aim of this trial is to assess the efficacy and safety of precision neuromodulation for alleviating core symptoms in patients with autism spectrum disorder (ASD) who also have intellectual or developmental delay. The neuromodulation will be administered using intermittent theta burst stimulation (iTBS) targeting the left dorsolateral prefrontal cortex (DLPFC), guided by personalized Brain Functional Sector (pBFS) technology.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * 6-30 years old * Have the diagnosis of autism spectrum disorder * ADOS-2 score is higher than the ASD cut-offs * Comorbid with intelligent disorder, IQ/DQ \< 70 * Primary environmental language is Chinese * Participant's parents or other legal guardians give informed consent Exclusion Criteria: * Genetic Disorders, such as (e.g., Down syndrome, Fragile X syndrome, Rett syndorme), Current or history of severe ADHD, tourette syndrome, psychotic disorders (e.g., schizophrenia, schizoaffective disorder, bipolar disorder) * Severe self-injury or suicidal behavior exhibited within the past year * Significant visual, auditory, deafness or motor disability that prevent them from following study procedures * Current or history diagnosis of epilepsy * Known severe physical diseases, particularly those affecting the brain * Metal implantation contradicted by MRI or TMS, such as artificial cardiac pacemakers, stents, cochlear implants * Respiratory or circulatory conditions increasing sedation risk, such as Apnea syndrome, severe snoring, or other relevant diseases * All legal guardians are illiterate, unable to read informed documents or complete questionnaires independently * Received transcranial magnetic stimulation (TMS), transcranial current stimulation (tCS), focused ultrasound (FUS), or other neuromodulation treatment in the last 3 months * Current participation in other clinical trials
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What it tests

  • active iTBS treatment
  • sham iTBS treatment
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Where

6 sites
Fujian Children's Hospital
Fuzhou, China
Fujian Maternity and Child Health Hospital
Fuzhou, China
Hebei Provincial Mental Health Center
Baoding, China
Xi'an TCM Hospital of Encephalopathy
Xi'an, China
Jining Medical University
Jining, China
Linyi Hedong Rehabilitation Hospital
Linyi, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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