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TREAT-SC: Early, Short Course Oral Dexamethasone for the Treatment of Sydenham Chorea in Children

RecruitingPhase 3Ages 4 Years - 17 YearsAllStarship Child Health, Te Toka Tumai Auckland
NCT06259006 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to find out whether an early three-day course of an oral steroid medication (dexamethasone) can improve the physical and mental recovery and wellbeing for children with Sydenham's chorea. Sydenham's chorea is a condition that impacts approximately 12% of children with acute rheumatic fever. It is caused by inflammation in the brain following an abnormal immune response to Group A streptococcus bacterial infection. Sydenham's chorea is a movement disorder that causes children's faces, hands, and feet to move quickly and uncontrollably, and can also affect mood and concentration. The physical recovery from Sydenham's chorea can take two to six months but the mental recovery (e.g. mood and concentration) can take longer to resolve. Sydenham's chorea remains endemic in Māori, Pacific Islander, Aboriginal and Torres Strait Islander children in New Zealand and Aus

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Sydenham's chorea of any severity diagnosed by a paediatrician or neurologist based on national ARF guidelines 2. Child or adolescents aged 4 years to \<18 years of age Exclusion Criteria: 1. Administered steroids or intravenous immunoglobulin since onset of the current Sydenham's chorea episode 2. Evidence of concomitant severe, acute infection 3. History of hypersensitivity to dexamethasone or its excipients 4. Pregnancy 5. Confirmed exposure of an unimmunised child to measles, mumps, rubella or chickenpox within the previous four weeks 6. Receipt of a live vaccine within the previous four weeks 7. Medical condition or treatment with medication which in the opinion of the trial investigators would make the child unsuitable for the trial
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What it tests

  • Dexamethasone Oral
  • Placebo
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Where

17 sites
Royal Darwin Hospital
Darwin, Australia
KidzFirst Hospital
Auckland, New Zealand
Starship Child Health, Te Toka Tumai, Auckland
Auckland, New Zealand
Waitākere Hospital
Auckland, New Zealand
Gisborne Hospital
Gisborne, New Zealand
Waikato Hospital
Hamilton, New Zealand
Hawkes Bay Fallen Soldiers' Memorial Hospital
Hastings, New Zealand
Hutt Hospital
Lower Hutt, New Zealand

…and 9 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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