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Dexamethasone and Pregnancy: Maternal Effects

Recruitingn/aAges 18 Years - anyFemaleAssistance Publique - Hôpitaux de Paris
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In plain words

What the trial is, and whether it could suit you

This study will analyze obstetric, endocrine and metabolic follow-up data in women treated with DEX. It will reveal the prevalence and importance of weight gain, insomnia, edema, stretch marks, arterial hypertension and gestational diabetes, describe pregnancy outcome, and analyze the corticotropic axis during and up to 3 months after pregnancy, with the aim of improving the management of these women and preventing comorbidities. A few studies suggest problems in women treated with DEX during pregnancy. However, all these studies are retrospective, based on self-questionnaires, and have not evaluated all pregnancy outcomes. Moreover, it would appear that a third of women treated with DEX no longer wish to resume the treatment (8). Compliance with treatment is strongly linked to its efficacy. It is therefore important to start investigating the pregnancy outcomes of women treated with DE

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Femme majeure (âge ≥ 18 ans) 2. Grossesse avec indication de traitement anténatal par dexaméthasone (DEX) en accord avec le PNDS : * Mutation sévère du gène CYP21A2 chez chacun des parents * Fœtus féminin 3. Grossesse unique 4. Ayant commencé un traitement anténatal par DEX depuis au moins 24h Exclusion Criteria: 1. Contraindication to dexamethasone treatment 2. Objection to use of data 3. Persons under legal protection (curatorship, guardianship), court-appointed guardians
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What it tests

  • Not listed
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Where

17 sites
Hopital Haut Leveque - Endocrinologie
Bordeaux, France
Endocrinologie - Hospices civils de Lyon
Bron, France
Hospices civils de Lyon Biochimie et Biologie moléculaire UM Pathologies endocriniennes
Bron, France
Hospices civils de Lyon Laboratoire de Biologie Médicale Multi Sites
Bron, France
Hospices civils de Lyon Service de médecine de la reproduction
Bron, France
Endocrinologie - CHU Grenoble - Hôpital Michallon
Grenoble, France
Endocrinologie et médecine de la reproduction - Hôpital Bicêtre APHP
Le Kremlin-Bicêtre, France
Endocrinologie pédiatrique - Hôpital Bicêtre APHP
Le Kremlin-Bicêtre, France

…and 9 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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