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โ† Trials
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Neurocognitive Impairment After Ischemic Stroke

RecruitingNAAges 18 Years - 45 YearsAllCentre Hospitalier Universitaire de Nice
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In plain words

What the trial is, and whether it could suit you

Affecting more than 150,000 patients in France, stroke is a major public health issue and a leading cause of disability worldwide. In western countries, 80-85% of strokes are of ischemic subtype. This study will focus on young adults, aged 18-45, with a diagnosis of ischemic stroke. Studies assessing post-stroke cognition in young patients reported an alarming prevalence of cognitive impairment, affecting about 60% of stroke survivors between 4 and 12 months after the acute event. However, longitudinal data on neurocognitive trajectories (i.e., the evolution of cognitive impairment over time) in young patients with ischemic stroke are lacking. Collecting such data requires an exhaustive neuropsychological assessment and several functional evaluations, at different times, for the same patient. Repeated neurocognitive study of young patients with ischemic stroke will enable: a descriptio

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Age: 18 to 45 years. * Pathology: ischemic stroke diagnosed with brain MRI as per standard clinical practice, with or without occlusion of proximal artery, anterior or posterior circulation. * Ability to understand and complete study tests and questionnaires: fluent French speaker and reader. * All patients must be affiliated to a social security scheme. * Signature of informed consent form. Exclusion Criteria: * Pre-existing cognitive impairment (defined as CQI \<78 or clinical dementia). * Severe functional dependence prior to stroke (defined as Modified Rankin Scale MRS = score 5). * Any neurological or psychiatric comorbidity. * Sensory disorders: visual impairment, blindness, deafness. * Severe acquired phasic disorders: on the expressive oral side, in the presence of an inability to express oneself, which interferes with the collection of responses to neuropsychological tests; and on the receptive oral side, in the presence of an inability to understand the instructions of neuropsychological tests. Phasic functioning is systematically assessed during hospitalization by means of the NIHSS (score โ‰ค 2 on the "Language" sub-test), and will be rechecked clinically and psychometrically during neuropsychological assessments using the Language Screening Test (LAST) for both expression and oral comprehension. - Severe motor disorders: inability to mobilize the dominant upper limb for written neuropsychological tests. * Contraindication to MRI. * Pregnant women. * HIV-positive patients: interaction of infectious pathology on cognitive functioning. Declarative, no HIV tests will be performed. * Withdrawal of informed consent. * Consumption of alcohol and/or narcotics on the day of neuropsychological assessments.
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What it tests

  • Cerebral MRI
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Where

2 sites
cannes Hospital
Cannes, France
Nice University Hospital
Nice, France
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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