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Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

RecruitingNAAges 18 Years - anyAllJohns Hopkins University
NCT06263426 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with vs without HIV.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Participant meets local criteria for kidney transplant. * Participant is able to understand and provide informed consent. * Participant has documented HIV infection by any licensed assay or documented history of detectable HIV-1 RNA. * Participant is ≥ 18 years old. * HIV-1 RNA \< 50 copies/mL. Viral blips between 50-400 copies will be allowed as long as there are not consecutive measurements \> 200 copies/mL. * Participant is not suffering from significant wasting (e.g. body mass index \<21) thought to be related to HIV disease. Exclusion Criteria: * Participant has prior progressive multifocal leukoencephalopathy (PML), cryptosporidiosis of \> 1 month, or primary central nervous system (CNS) lymphoma. * Participant is pregnant or breastfeeding. * Past or current medical problems or findings from medical history, physical examination or laboratory testing that are not listed above, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study.
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What it tests

  • HIV D+/R+
  • HIV D-/R+
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Where

18 sites
University of Alabama at Birmingham
Birmingham, United States
University of California, Davis
Sacramento, United States
University of California, San Diego
San Diego, United States
University of California, San Francisco
San Francisco, United States
Mayo Clinic Florida
Jacksonville, United States
Northwestern University
Chicago, United States
Rush University Medical Center
Chicago, United States
Ochsner Clinic Foundation
New Orleans, United States

…and 10 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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