🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Prognostic Value of High-resolution Electrical Source Imaging on the Success of Pediatric Focal Epilepsy Surgery

RecruitingNAAges 2 Years - 17 YearsAllUniversity Hospital, Angers
NCT06271785 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

This study investigates the usefulness of high resolution electrical source imaging (HR-ESI) in the setting of presurgical evaluation of drug-resistant focal epilepsy in children. This method is based on an estimation of the intra-cerebral source that produces a signal recorded by scalp electrodes by solving the inverse problem, taking into account attenuation factors resulting from particular conductivity properties of the cerebral, peri-cerebral and cranial tissues. Electrical sources are then fused on structural magnetic resonance imaging (MRI). Scalp EEG recorded using 64 to 256 electrodes refers to as high resolution EEG (HR-EEG), leading to HR-ESI. Studies based on small population of children or on mixt population of children and adults showed that HR-ESI has accuracy values, i.e. percentage of true positives (electrical source localized in the brain area resected and success

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age≥2 and \<17 years; 2. Drug-resistant focal epilepsy (failure of at least 2 well-conducted drug trials); 3. Phase 1 pre-op evaluation with scalp video-EEG recording, MRI and PET-FDG suggesting that the patient could be a good candidate for epilepsy surgery; 4. Recent scalp EEG record (within 12 months) showing the presence of interictal spikes; 5. High-quality and recent (within 6 months) structural MRI with 3D-T1 sequences covering the whole brain and the scalp available. Exclusion Criteria: 1. Behavioral deficits making recording of scalp EEG impossible without sedation; 2. Informed consent form not signed by the parents; 3. Patient not affiliated to a social security system
💊

What it tests

  • HR-EEG recording
📍

Where

9 sites
Angers university hospital, Pédiatric department
Angers, France
Lille University Hospital, Clinical Neurophysiology Department
Lille, France
Civil Hospices of Lyon, Functional Neurology Department
Lyon, France
Marseille Timone University Hospital, Epileptology and Cerebral Rhythmology Department
Marseille, France
Nancy University Hospital, Neurology Department
Nancy, France
Paris Neck University Hospital, Pediatric department
Paris, France
Paris Robert-Debré University Hospital, Department of Physiology, Pediatric functional explorations
Paris, France
Rothschild Ophtalmologic Fondation, Pediatric neurosurgery Department
Paris, France

…and 1 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy