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Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)

RecruitingPhase 2, Phase 3Ages 21 Years - 55 YearsAllUniversity of California, San Diego
NCT06273527 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program that is designed as a cognitive training intervention and Group 2 will receive a similar computer-based exercise that researchers think will be less effective in training thinking skills (also known as a control or sham condition). Participants will be compared on cognitive performance and brain response during cognitive tasks from baseline to post-treatment.

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📋 Eligibility rules (as published)
Inclusion Criteria: * age 21-55 * fluent in English * diagnosis of mood, anxiety, or traumatic stress disorder * clinically elevated repetitive negative thinking * outpatient status * 6-week stability if taking selective serotonin reuptake inhibitor (SSRI) medications Exclusion Criteria: * past year diagnosis of severe alcohol or moderate or greater substance use disorder * lifetime history of psychotic or bipolar I disorder * acute suicidality necessitating immediate clinical intervention * neurodegenerative or neurodevelopmental disorders * history of moderate or severe traumatic brain injury or other known neurological condition * sensory deficits that would preclude completing tasks * conditions unsafe for completing MRI scanning (e.g., metal in body) * current pregnancy * currently receiving psychosocial treatment * currently receiving psychiatric pharmacotherapy, except SSRIs
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What it tests

  • COGENT
  • Sham Program
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Where

1 site
UC San Diego
San Diego, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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