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HONEY for the Treatment of POst-Tonsillectomy Pain

RecruitingNAAges 18 Years - anyAllEast and North Hertfordshire NHS Trust
NCT06275698 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Double-blind, randomised, placebo controlled, single-site trial in adults to compare the effect of Manuka honey with standard of care compared to placebo with standard of care on post-tonsillectomy pain and postoperative outcomes. Main aim is to investigate a potential improvement in post-tonsillectomy pain control, with a low cost and freely available alternative to conventional analgesics. Recent systematic review and multidisciplinary consensus suggest a potential role for the inclusion of honey for this purpose. Clinical efficacy over placebo remains to be conclusively demonstrated in robust clinical trials.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult (≥18years old at the time of giving consent) * Consented and listed for bilateral tonsillectomy or adenotonsillectomy * Tonsillectomy performed within the trial study period Exclusion Criteria: * Any concurrent Head \& Neck (H\&N) malignancy * Unilateral tonsillectomy * Pregnancy * Concurrent pharyngeal or upper aerodigestive tract biopsy * Robotic tonsillectomy * Previous H\&N malignancy * Previous H\&N radiotherapy * Type 1/2 diabetes mellitus * Known allergy to bee related products * Known allergy to golden syrup * History of chronic pain * History of fibromyalgia * Current usage of chronic (\>6weeks) analgesia * High-risk anaesthetic patients * Children or adolescents \<18years old * Adults unable to consent for themselves
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What it tests

  • Manuka honey MGO 1000
  • Sugar-based syrup, thickened with sodium alginate and flavoured with honey flavouring
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Where

1 site
Lister Hospital
Stevenage, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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