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LPFC Organization in Emotion-Duration Difference Estimation

RecruitingNAAges 18 Years - 45 YearsAllUniversity of California, Santa Barbara
NCT06276400 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

To support optimal behavior in daily life, goals and responses following emotional events should ideally incorporate not only the valence and intensity of prior emotional episodes but also their temporal features, such as the relative duration of positive vs. negative attributes. However, how specific brain regions contribute to the integration of temporal and emotional information and promote goal-directed response remains unknown. The goal of this study is to examine how specific brain regions track both emotional and temporal information of dynamic emotional events to inform other related brain regions to guide goal-oriented and context-appropriate actions. The investigators will scan healthy human participants using functional MRI (fMRI) while they view emotional image sequences and track the associated emotional and temporal (duration) information, and act accordingly. The investig

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📋 Eligibility rules (as published)
Inclusion Criteria: * right-handed * between the ages of 18 and 45 * be a fluent English speaker * have normal to corrected-to-normal vision. Exclusion Criteria: * if they report a current or prior diagnosis of a psychiatric disorder requiring hospitalization and/or are currently using psychiatric medication; o If they report a history of or current neurological disease (i.e., stroke, concussion, epilepsy, major head trauma, complicated migraine); * If they ever had a seizure; * If they have a family history of epilepsy or seizure disorders; * If they have a history of fainting; * If they are sleep deprived (TMS only); * If they have a history of prior surgery with metal clips, implants, devices, prosthetics, cardiac or neural implants (e.g., pacemaker; neurostimulator), or cochlear implants; * If they are unable to safely and comfortably complete an MRI: have metal in the body, recent surgery, presence of surgically implanted devices not cleared for MRI, extreme claustrophobia, if they report tattoos of the head or neck region, non-removable metal piercing anywhere on the body * Women will be asked to self-report their pregnancy status and have the option to take a pregnancy test if they wish. If there is a chance a participant is pregnant, they will not be scanned. * As part of the newly adopted UCSB BIC prescreening procedure, participants will be asked about their history of hearing issues (including loss, hyperacuity, sensitivity to loud noises, history of tinnitus (ringing in ears), job with high noise exposure, and chronic migraines. Participants will be excluded if one or more hearing issues are reported.
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What it tests

  • Emotion valence
  • Time
  • TMS Stimulation
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Where

1 site
University of California, Santa Barbara
Santa Barbara, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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