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Exercise for Improving Long-course Chemoradiotherapy Efficacy in People With Locally Advanced Rectal Cancer

RecruitingEARLY Phase 1Ages 18 Years - anyAllUniversity of Hull
NCT06276686 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a single arm feasibility study of exercise for improving long- course neoadjuvant chemoradiotherapy (NACRT) efficacy in people diagnosed with locally advanced rectal cancer. The study aims to recruit up to 30 patients from the Queen's Centre for Oncology and Haematology of Castle Hill Hospital, Cottingham, diagnosed with locally advanced rectal cancer. Consenting patients will be provided with an 11-week course of structured aerobic exercises and resistance training in the periods before, during and after their chemoradiotherapy treatment. The patients will be followed up for 6 months post long course neoadjuvant chemoradiotherapy (NACRT), with a total of 3 assessment periods.

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18 years or older * Have been diagnosed with locally advanced rectal cancer using MRI (Magnetic Resonance Imaging) and histological finding * Have been offered long-course neoadjuvant chemoradiotherapy in the Queens Centre, Castle Hill Hospital * Willing and able to comply with all study requirements * Able and willing to voluntarily give informed consent to take part. Exclusion Criteria: * Inability to understand basic written and spoken English, as research materials will all be written in English. * Any movement deficiencies limiting ability to engage in exercise. * Impaired cognition and/or capacity limiting ability to provide informed consent. * Cardiovascular and/or cardiopulmonary conditions that will impede ability to safely perform exercise. * Severe psychiatric disorders. * With any other health condition which oncologists and research team agrees will impede ability to safely perform exercises. * Presence of metastatic cancer.
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What it tests

  • Supervised Vigorous intensity aerobic interval exercise
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Where

1 site
Castle Hill Hospital
Cottingham, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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