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PT-STRESS Study: Predicting Treatment Success and Dealing With Non-response in the Treatment of PTSD

RecruitingNAAges 18 Years - 65 YearsAllUniversity of Groningen
NCT06279598 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this study is to increase understanding of the effectiveness and efficiency of psychological treatment for adult patients with posttraumatic stress disorder -PTSD- and to make it more personalized. Key questions: 1. Which predictors of treatment success influence treatment outcome of patients with PTSD who receive the three psychotherapeutic treatments investigated in this study? 2. Which specific moderators can be identified with regard to the different psychotherapies (Eye Movement Desensitization and Reprocessing -EMDR-; Prolonged Exposure -PE-; and Interpersonal Psychotherapy -IPT- in the second phase)? 3. In patients with PTSD, does offering another proven effective form of trauma-focused psychotherapy (PE after EMDR, or EMDR after PE) improve symptoms following insufficient response to a first trauma-focused treatment? 4. Is switching from a trauma-focused therapy to a

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults between the ages of 18 and 65 who were classified with a primary diagnosis of PTSD (based on the DSM-5 criteria). * Adults who are willing to participate in the study (informed consent) Exclusion Criteria: * Insufficient proficiency in the Dutch language. * Patients who cannot follow the treatment protocol (for example due to prolonged absence) are excluded from the study. * Patients who use medication that is not stable. If properly set to the last prescribed medication by the doctor there will be advised to continue and referably not change the medication and its dose during treatment, unless necessary in connection with side effects, crisis, etc. * Patients that already received an evidence-based form of trauma-oriented treatment for PTSD in the past year and for sufficient treatment duration, in accordance to the Dutch professional practice guidelines (reference: Akwa GGZ (2020, December 1). GGZ Standaarden. Psychotrauma- en stressorgerelateerde stoornissen. Retrieved September 29, 2022, from https://www.ggzstandaarden.nl/zorgstandaarden/psychotrauma-en-stressorgerelateerde-stoornissen/introductie). * Patients with serious suicidality that requires acute intervention and structural addition of additional treatment interventions. * Patients with an intellectual disability. * Patients with a serious addiction as a comorbid problem. * Patients with an acute mania or a psychotic state.
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What it tests

  • Prolonged Exposure therapy
  • Eye Movement Desensitization Reprocessing (EMDR)
  • Interpersonal Psychotherapy (IPT)
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Where

1 site
Dimence
Deventer, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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