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Evaluation of Thiosulfate Enhanced Organ Preservation Solution in Kidney Transplantation

RecruitingNAAges 18 Years - anyAllAlp Sener
NCT06288152 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

End-stage renal disease (ESRD) is a significant clinical problem for which dialysis or transplantation is required. The current need for kidneys for transplantation vastly exceeds the supply available from live donors, necessitating the use of kidneys from deceased donors. However, kidneys from deceased donors are associated with reduced viability, as lack of blood supply upon cardiac death increases tissue damage. In addition, the standard protocol for cold preservation of donor kidneys between procurement and transplantation increases the risk of delayed donor kidney function by 23% for every 6-hours of storage. Moreover, compared to other organs, the kidney is particularly prone to transplantation-induced injury due to its high metabolic activities and oxygen consumption. Hence, any minor disturbances in blood supply can easily lead to kidney injury. Therefore, it is not surprising th

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18 years of age and over * End-Stage Renal Disease * Receiving a kidney transplant from a deceased donor (NDD or DCD) Exclusion Criteria: * Under 18 years of age * Inability to provide informed consent * Living donor kidney recipients * Pregnant individuals * Known allergy to study medication or its components (non-medicinal ingredients) * Multiorgan transplant patients such as simultaneous kidney pancreas or liver kidney transplants * Currently enrolled in another interventional transplant clinical trial, or another clinical trial that in the opinion of the QI and PI would greatly impact the results of this study.
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What it tests

  • Sodium Thiosulfate
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Where

1 site
London Health Sciences Centre
London, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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