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Nerve Transfer to Improve Function in High Level Tetraplegia

Recruitingn/aAges 18 Years - 80 YearsAllWashington University School of Medicine
NCT06288763 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury. Participants will: * undergo standard of care pre- and post-op testing and study exams * complete pre- and post-questionnaires * undergo standard of care nerve transfer surgeries * follow-up with surgeon at 6/12/18/24/36 and potentially at 48 months * attend therapy at local therapist for up to 2 years postop.

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18-80 years of age * High cervical SCI (motor level C1-C4) * Motor complete SCI AIS grade A-B * Plateaued spontaneous recovery for at least 6 months of non-operative therapy * SCI greater than 6 months and fewer than 60 months since injury * At least MRC 4/5 donor strength * Mentally and physically willing and able to comply with evaluations Exclusion Criteria: * Active infection at the operative site or systemic infection * Any return or ongoing recovery of distal motor function * Significant joint contractures and/or limitations in passive range of motion in the arm * Mentally or physically compromised making it impossible to complete study activities * Immunologically suppressed * Currently undergoing long-term steroid therapy * Active malignancy * Pregnancy
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What it tests

  • Not listed
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Where

10 sites
Stanford University
Stanford, United States
University of Miami
Miami, United States
Johns Hopkins University
Baltimore, United States
University of Michigan
Ann Arbor, United States
Washington University in St. Louis
St Louis, United States
Wake Forest Medical Center
Winston-Salem, United States
University of Pennsylvania
Philadelphia, United States
Houston Methodist
Houston, United States

…and 2 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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