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Gender-Affirming Hormone Therapy and Its Impact on Myocardial Mass and Cardiac Function, Heart, Liver and Pancreatic Fat Content

Recruitingn/aAges 18 Years - anyAllMedical University of Vienna
NCT06291675 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Gender affirming hormone therapy (GAHT) leads to profound changes in sex hormone levels, carrying a wide range of implications for major physiological processes in the body. GAHT has been shown to be associated with changes in cardiovascular parameters, the insulin system, body composition, and the psychological state. However, despite the fact that GAHT is usually a long-term intervention, the majority of the research concerns itself with an overall short duration of the therapy and the data on the mid- to long-term effects of GAHT is scarce. Objectives: The study aims to investigate the effects of gender affirming hormone therapy on the cardiovascular risk profile, insulin system, body composition, various metabolic parameters, and the psychological state after 2, 5, and 10 years of the treatment. Study design: The study is designed as an observational longitudinal monoce

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📋 Eligibility rules (as published)
Inclusion Criteria: * participation in our pilot study * ongoing gender affirming hormone therapy during the last 2 years * willingness and competence to sign the informed consent form. Exclusion Criteria: * age \< 18 years * non-MRI conditional implants, grafts, and/or devices * non-MRI conditional tattoos * claustrophobia * current substance abuse * pregnancy * failure to comply with the study protocol and/or not following the instructions of the study team.
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What it tests

  • gender-affirming hormone therapy
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Where

1 site
Chiari Stoffwechselambulanz, Medical University of Vienna
Vienna, Austria
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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