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โ† Trials
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Secondary Interval Cytoreductive Surgery in Platinum-sensitive Recurrent Epithelial Ovarian Cancer

RecruitingNAAges 18 Years - anyFemaleThe University of Hong Kong
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In plain words

What the trial is, and whether it could suit you

About 80% of advanced ovarian cancer patients recurred in 2-3 years. Secondary cytoreduction benefits selected patients who have high chance of complete resection. Whether secondary interval surgery can be used at recurrence is not known.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Histologically diagnosed EOC, fallopian tube or primary peritoneal carcinoma * \>= 3 cycles of platinum-based chemotherapy, with or without bevacizumab and / or PARPi, at primary setting * Platinum-free interval should be \>=6 months from the last dose of platinum-based chemotherapy * Upfront SCR not feasible * Patients should have Eastern Cooperative Oncology Group (ECOG) performance score 0 to 2 within 28 days prior to recruitment. * Patients must have adequate bone marrow, renal, hepatic and neurological function within 28 days prior to the start of treatment. Exclusion Criteria: * Non-epithelial or borderline tumors are excluded * Patients who have with concurrent malignancy within five years (except for basal or squamous cell skin cancer, in-situ breast cancer, stage 1a grade 1-2 endometrioid endometrial carcinoma without lymphovascular invasion) are excluded. * Patients using more than one line of chemotherapy are excluded. * Patients who have platinum-resistant or refractory recurrence are excluded. * Patients having second relapse or beyond are excluded. * Patients who have contraindications to operation, e.g., unresolved thrombocytopenia, bowel obstruction in the last 4 weeks prior to enrolment
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What it tests

  • Carboplatin or cisplatin
  • Paclitaxel, gemcitabine or liposomal doxorubicin with or without bevacizumab or biosimilar
  • Bevacizumab or biosimilar
  • Cytoreductive surgery
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Where

1 site
The University of Hong Kong
Hong Kong, Hong Kong
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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