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Massed Prolonged Exposure for PTSD in Substance Use Treatment

RecruitingNAAges 18 Years - anyAllVeterans Medical Research Foundation
NCT06296186 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn if receiving Prolonged Exposure Therapy for PTSD in massed format (multiple sessions weekly) is as effective as receiving it with sessions once per week among veterans with PTSD and substance use disorder in intensive outpatient substance use treatment. The main questions it aims to answer are: * Will the massed format help participants complete and benefit from Prolonged Exposure in terms of PTSD symptoms? * Will it help participants reduce substance use? Participants who are in intensive substance use treatment will be asked to complete Prolonged Exposure with either weekly sessions or multiple sessions per week.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Veterans * age 18+ * who have served since September 2001 * who are enrolled in a SUD IOP at a participating VA * meet DSM-5 criteria for a current SUD (Tobacco Use Disorder alone not sufficient for inclusion) * meet DSM-5 criteria for PTSD * report substance use at least 20 of the last 90 days * are able to give informed consent. Exclusion Criteria: * severe cognitive impairment * current suicidal or homicidal intent requiring immediate treatment * current unstable psychotic or manic symptoms not attributable to SUD
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What it tests

  • Prolonged Exposure Therapy
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Where

6 sites
VA San Diego Healthcare System
San Diego, United States
VA Tampa Healthcare System
Tampa, United States
VA Atlanta Healthcare System
Atlanta, United States
Hines VA Healthcare System
Chicago, United States
New Orleans VA Medical Center
New Orleans, United States
Cleveland VA
Cleveland, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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