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The Krill Ageing Muscle Mechanisms (KAMM) Study

RecruitingNAAges 65 Years - 90 YearsAllUniversity of Glasgow
NCT06296875 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to determine the mechanisms via which krill oil supplementation increases muscle strength and whether this translates to improvements in gait and functional characteristics in older adults. The studies we will carry out will establish, in healthy older adults, the effects of 6 months of supplementation with krill oil Objective 1) Muscle structure and function Hypothesis: Krill oil supplementation will increase muscle size and strength alongside positive changes in muscle architecture (pennation angle and fascicle length). Objective 2) Neuromuscular control and central nervous system (CNS) function Hypothesis: Krill oil supplementation will improve Neuromuscular Junction (NMJ) transmission stability and increase central drive and intramuscular coherence, as a measure of muscle synergy. Objective 3) Gait and functional characteristics Hypothesis: Krill oil supplementatio

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📋 Eligibility rules (as published)
Inclusion Criteria: * body mass index (BMI) \</= 30 kg/m2 * Age \>/= 65 years * Capacity to consent * Living within the Glasgow area Exclusion Criteria: * Diabetes mellitus * Severe cardiovascular disease * Seizure disorders * Uncontrolled hypertension (\>150/90mmHg) * Active cancer or cancer that has been in remission \<5 years * Participation in any resistance exercise training within the last 6 months * Impairments which may limit ability to perform assessments of muscle function * Dementia * Fish/shellfish allergy * Taking medication known to affect muscle (e.g. steroids, Selective serotonin reuptake inhibitors) or anticoagulants (e.g. warfarin) * Taking omega-3 supplements in the last 3 months * Regularly consuming 1 or more portions of oily fish per week * Not able to understand English
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What it tests

  • Vegetable oil
  • Krill oil
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Where

1 site
University of Glasgow
Glasgow, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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