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โ† Trials
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Study of Arlocabtagene Autoleucel (BMS-986393) a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma

RecruitingPhase 2Ages 18 Years - anyAllJuno Therapeutics, Inc., a Bristol-Myers Squibb Cโ€ฆ
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to evaluate the effectiveness and safety of Arlocabtagene Autoleucel (BMS-986393) in participants with relapsed or refractory multiple myeloma.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria * Documented diagnosis of multiple myeloma (MM) as per International Myeloma Working Group (IMWG) criteria. * Received at least 4 classes of MM treatment \[including immunomodulatory drug (IMiD), proteasome inhibitor (PI), anti CD38 mAb, anti-BCMA therapy, and at least 3 prior lines of therapy (LOT). * Documented disease progression during or after their last anti-myeloma regimen as per IMWG 2016 criteria. * Participants must have measurable disease during screening. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Exclusion Criteria * Active or history of central nervous system involvement with MM. * Active systemic fungal, bacterial, viral, or other infection despite appropriate anti-infective treatment at the time of leukapheresis. Participants with severe infection, severe sepsis or bacteremia in the last 28 days prior to leukapheresis are excluded. * Received any prior therapy directed at G protein-coupled receptor class C, group 5, member D (GPRC5D) or has received other prior treatment for MM without the required washout prior to leukapheresis. * Other protocol-defined Inclusion/Exclusion criteria apply.
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What it tests

  • Arlocabtagene Autoleucel
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Where

52 sites
University of Alabama at Birmingham
Birmingham, United States
Banner MD Anderson Cancer Center
Gilbert, United States
University of Arkansas for Medical Sciences
Little Rock, United States
UCLA Hematology/Oncology - Westwood (Building 200 Suite 214)
Los Angeles, United States
UCSF Helen Diller Medical Center at Parnassus Heights
San Francisco, United States
Colorado Blood Cancer Institute
Denver, United States
Mayo Clinic in Florida
Jacksonville, United States
Miami Cancer Institute at Baptist Health, Inc.
Miami, United States

โ€ฆand 44 more on ClinicalTrials.gov.

๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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