Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement

Inclusion Criteria: * The patient's age (18-26). Severe or very severe irregularity of the upper incisors greater than (7 mm) according to Little's index, so it is recommended to extract the upper first premolar. * Class I or Class II malocclusion, first model according to Angle, with skeletal class I or II and a normal or mild vertical growth pattern. * All permanent upper teeth, up to the first molar, are present, with the possibility of attaching brackets to all teeth in a correct position. * The patient has good oral health. Exclusion Criteria: * • The presence of any systemic disease that affects orthodontic dental movement. * Severe malalignment of one of the teeth (palatal quadrant, ectopic canine, ectopic premolar). * The patient has undergone previous orthodontic treatment. * The patient is subject to any drug treatment that may affect orthodontic dental movement (cortisone, non-steroidal anti-inflammatory drugs). * The patient has poor oral health. * Commitment to periodic follow-up appointments.