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End Tidal Carbon Dioxide Concentration and Depth of Anesthesia in Children

RecruitingNAAges 3 Years - 11 YearsAllUniversity of British Columbia
NCT06303518 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Carbon Dioxide (CO2) is a by-product of metabolism and is removed from the body when we breathe out. High levels of CO2 can affect the nervous system and cause us to be sleepy or sedated. Research suggests that high levels of CO2 may benefit patients who are asleep under anesthesia, such as by reducing infection rates, nausea, or recovery from anesthesia . CO2 may also reduce pain signals or the medication required to keep patients asleep during anesthesia; this has not been researched in children. During general anesthesia, anesthesiologists keep patients asleep with anesthetic gases or by giving medications into a vein. These drugs can depress breathing; therefore, an anesthesiologist will control breathing (ventilation) with an artificial airway such as an endotracheal tube. Changes in ventilation can alter the amount of CO2 removed from the body. The anesthesiologist may also monito

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📋 Eligibility rules (as published)
Inclusion Criteria: * Children aged 3 - 11 years undergoing non- or minimally-stimulating elective procedures, defined as anesthesia without skin incision or painful manipulation (e.g., non-invasive imaging, auditory brainstem response testing), middle ear surgery, surgery with effective local or regional anesthesia before surgical incision (e.g dental procedures with local anesthetic infiltration, urology with regional block). * American Society of Anesthesiologists (ASA) physical status I and II * TIVA technique appropriate throughout induction and maintenance of anesthesia * Controlled ventilation via endotracheal tube * Anticipated surgical time ≥ 90 minutes: to allow time for anesthetic induction and subsequent testing and washout periods at all three EtCO2 levels. Exclusion Criteria: * Need for inhalational induction of anesthesia * Sedative premedication * Use of ketamine intraoperatively * Unable to place BIS electrodes due to surgical site or other contraindications (e.g., MRI) * Allergy to study drugs (propofol, remifentanil, lidocaine) * Depression of conscious level for any reason * BMI \<5th or \>95th centile for age * History of obstructive or central sleep apnea * Known or suspected raised intracranial pressure * Recent or historical traumatic brain injury
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What it tests

  • High normal ETCO2: ETCO2 50 mmHg (+/- 3mmHg)
  • Normal ETCO2: ETCO2 40 mmHg (+/- 3mmHg)
  • Low Normal ETCO2: ETCO2 30 mmHg (+/- 3mmHg)
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Where

1 site
BC Children's Hospital
Vancouver, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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