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Effect of Blue Light on Vagus Nerve Stimulation in Patients With Refractory Epilepsy

RecruitingNAAges 18 Years - 60 YearsAllCliniques universitaires Saint-Luc- Université Ca…
NCT06304389 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Vagus nerve stimulation (VNS) is an adjunctive treatment for refractory epilepsy. Although widely used, there is still a substantial number of patients with insufficient response. Light, and particularly blue light, can stimulate alertness, attention and cognition through modulation of anatomical targets which are common to the vagal afferent network. This project aims at understanding how exposure to blue enriched light may influence VNS effects in patients with refractory epilepsy by exploring the modulation of a series of biomarkers of VNS action. This could possibly lead to new therapeutic strategies to increase efficacy of VNS.

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📋 Eligibility rules (as published)
Inclusion Criteria: Patients: VNS implanted since at least 3 months age \>18-60 years; IQ \>55 on Wechsler scale (normal status or mild cognitive impairment) healthy participants aged between 18 and 35 years without any medical history (neurological / psychiatric disease) Exclusion criteria: Patients: other medical implanted devices than VNS, ocular diseases Helthy participants: medical implanted devices, cerebral trauma, ocular disease
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What it tests

  • electroencephalography, electrocardiogram, pupillometry, evoked potentials, light administration
  • transcutaneous vagus nerve stimulation, electroencephalography, pupillometry, electrocardiogram, light administration
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Where

1 site
Cliniques Universitaires Saint Luc
Woluwe-Saint-Lambert, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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