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Effect of Vitamin C on Pain Reduction After an Emergency Department Visit

RecruitingNAAges 18 Years - anyAllCentre Integre Universitaire de Sante et Services…
NCT06306183 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Musculoskeletal (MSK) injuries such as sprains, strains, bruises, and fractures are among the most common reasons people visit the emergency department. These injuries often cause significant pain in the first few days, making it difficult to move, work, or sleep. Usual pain medications like ibuprofen or acetaminophen can help, but they are not safe or effective for everyone. Some people cannot take them because of heart, kidney, stomach, or liver problems. Others still experience strong pain despite treatment. Because of these limits, some patients receive opioids, which can cause side effects and carry a risk of dependence. Safer and more accessible options are needed. Vitamin C is widely known for supporting the immune system, but research suggests it may also help reduce pain and inflammation. Studies in surgical patients have shown that vitamin C can lower pain levels, reduce the n

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age ≥ 18 years old 2. Presenting to the ED with acute MSK pain of ≤ 48 hours duration at triage 3. Verbal numerical rating scale pain intensity at triage of ≥ 4 on a 0-10 scale 4. Triaged to the ambulatory section of the ED 5. Able to communicate in French or English Exclusion Criteria: 1. Usage of Vit C supplements in the last week 2. Active cancer 3. Treated with opioids for any pain within 24 hours prior to recruitment 4. Treatment for chronic pain 5. Unable to fill out a pain intensity diary or unavailable for follow-up 6. Allergy to milk (lactose in the placebo) or Vit C 7. Treated with cyclosporine or warfarin 8. Pre-existing oxalate nephropathy, liver cirrhosis or hemochromatosis 9. Hospitalized after clinician evaluation
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What it tests

  • Vitamin C
  • Placebo
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Where

4 sites
The Ottawa Hospital - General and Civic Campus
Ottawa, Canada
Hôtel-Dieu de Lévis
Lévis, Canada
Hopital du Sacre-Coeur de Montreal
Montreal, Canada
CHU de Québec - Université Laval
Québec, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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