Safety and Efficacy of Decentralized HCV Treatment vs Standard-of-Care in Rio de Janeiro (Brazil)

Study I and Sub-Study Inclusion Criteria: \- Age between 18-79 years-old Exclusion Criteria: * Presence of a disease that need urgent/emergency treatment and/or acute febrile illness, such as COVID-19, Dengue, Zyca virus infection or Chikungunya * Lack of capacity to sign the informed consent or refuse to participate Study II Inclusion Criteria: * Age between 18 and 79 years old. * Presence of active/chronic hepatitis C, defined by a positive HCVab test and detectable HCV-RNA Exclusion Criteria: * Children and adolescents (\< 18 years old) * Pregnancy, defined by a positive β-HCG urinary test * Lactating individuals * Co-infection with HBV or HIV * Regular use of medications with potential drug interactions or contraindication for co-administration with SOF/VEL * Presence of severe acute illness, active neoplasia, solid organ transplant, or use of immunosuppressive medications * Presence of clinical signs of decompensated liver cirrhosis (ascites, hepatic encephalopathy, report of a recent episode of gastrointestinal bleeding within the last 12 weeks)