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A Study to Investigate ANS014004 in Participants With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1Ages 18 Years - anyAllAvistone Biotechnology Co., Ltd.
NCT06307795 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a Phase 1, first-in-human, open-label, multi-center study with the aim of exploring the safety, tolerability, PK, and preliminary anti-tumor activity of ANS014004 as a single agent in participants with locally advanced or metastatic solid tumors.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years * Eastern Cooperative Oncology Group (ECOG) Performance Status: 0-1 * Life expectancy ≥ 12 weeks * Measurable disease per RECIST v1.1 * Adequate organ and marrow function as defined in the protocol * With a pathogenetic MET alteration or ROS1 alteration or NTRK alternation Exclusion Criteria: * Active infection including tuberculosis and HBV, HCV or HIV * Known active or untreated CNS metastases * Participants with carcinomatous meningitis or meningeal metastases, or spinal cord compression * Participants with serious cardiovascular or cerebrovascular diseases
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What it tests

  • ANS014004
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Where

15 sites
University of California, San Diego
San Diego, United States
Sarah Cannon Research Institute
Denver, United States
Advent Health
Orlando, United States
Henry Ford Health Cancer
Detroit, United States
NYU Langone Health
New York, United States
The University of Texas - MD Anderson Cancer Center
Houston, United States
NEXT Oncology, Virginia
Fairfax, United States
Swedish Cancer Institute
Seattle, United States

…and 7 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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