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โ† Trials
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A Study of JNJ-87704916, as Monotherapy and in Combination for Advanced Solid Tumors

RecruitingPhase 1Ages 18 Years - anyAllJohnson & Johnson Enterprise Innovation Inc.
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to determine the safety, feasibility, recommended dose(s) and regimen(s) of JNJ-87704916 as monotherapy and in combination with cetrelimab.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * For Part 1: Individuals with a diagnosis of advanced or metastatic solid tumor exhausting all available standard of care therapy; Part 2: Individuals with histologically or cytologically confirmed metastatic or locally advanced NSCLC * Have at least 1 injectable tumor * Eastern cooperative oncology group (ECOG) performance status of grade 0 or 1 * A participant who can have children must have a negative pregnancy test before the first dose of study treatment and during the study * Thyroid function laboratory values within normal range except for participants on thyroid hormone replacement therapy Exclusion Criteria: * Active disease involvement of the CNS (example, primary central nervous system tumors, metastases, leptomeningeal disease). Some exceptions are allowed * Prior history of, or active, significant herpetic infections (example, herpetic keratitis or encephalitis) or active herpetic infections that require ongoing systemic anti-viral therapy * Active infection or condition that requires treatment with systemic anti-infective agents (example, antibiotics, antifungals, or antivirals) within 7 days prior to the first dose of study treatment or chronic use of anti-infective agents * History of solid organ or hematologic stem cell transplantation * Known positive test result for human immunodeficiency virus (HIV) or other immunodeficiency syndrome * History of allergy to protein-based therapies or history of any significant drug allergy (such as anaphylaxis, hepatotoxicity, or immune-mediated thrombocytopenia or anemia)
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What it tests

  • JNJ-87704916
  • Cetrelimab
  • Standard of Care PD(L)-1
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Where

10 sites
NYU Langone Health
New York, United States
Fox Chase Cancer Center
Philadelphia, United States
UPMC Cancer Centers
Pittsburgh, United States
MD Anderson Cancer Center
Houston, United States
Toronto General Hospital
Toronto, Canada
Centre Hospitalier de l'Universite de Montreal
Montreal, Canada
Gustave Roussy
Villejuif, France
Hosp Univ Vall D Hebron
Barcelona, Spain

โ€ฆand 2 more on ClinicalTrials.gov.

๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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