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Longitudinal Monitoring During Intermittent Fasting Protocols in Obese Adults

RecruitingNAAges 18 Years - 50 YearsAllUniversity of Zurich
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In plain words

What the trial is, and whether it could suit you

LIMITFOOD2 is a randomized clinical intervention study that investigates the effects of two different intermittent fasting protocols compared to a control group on the health of obese adults. A total of 90 participants will be randomized into three equally sized groups: a modified alternate day fasting, a time-restricted eating and a control group, receiving general weight-loss counseling.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Age between 18-50 years, both inclusive * Obese, BMI between 30 and 40 kg/m\^2 (obesity grade I or II), both inclusive * Non-smoker * Good knowledge of German or English language * Stable weight change (change \< +/- 3% current bodyweight) for 3 months prior to the study * HbA1c \< 6.5% without glucose lowering medication * LDL-cholesterol \< 4.6mmol/l without lipid lowering medication Exclusion Criteria: * Participants who have a fasting period of \> 12h per day on a regular basis and do not eat at least three main meals per day. * Current habitual use of dietary supplements (e.g., vitamins, minerals) and/or unwillingness to cease intake of dietary supplements. * Antibiotics intake during 3 months prior to the study due to possible interference with metabolic parameters * Food intolerances, allergies and sensitivities (severe food allergies) or dietary restrictions (e.g. vegan lifestyle) * Acute or chronic infections, malignant disease, renal, hepatic (more than two-fold increased transaminases), pulmonary, neurological (epilepsy) or psychiatric diseases, manifested atherosclerosis, or any other disease precluding participation in the study. * Diabetes * Known alcohol, substance or drug abuse, concomitant medication * More than four hours of physical exercise per week * Women who are pregnant, breast-feeding or aiming to become pregnant during course of the trial * Women and men on hormonal supplementation * Women with an irregular menstrual cycle according to the FIGO criteria * Therapy with antidepressants within the past 6 months * Regular therapy with acetylsalicyclic acid or current medication to regulate blood sugar, blood pressure or lipids * Participants likely to fail to comply with the study protocol * Participants who do not give informed consent
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What it tests

  • Modified Alternate Day Fasting
  • Time-Restricted Eating
  • Weight-loss counseling
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Where

1 site
Department of Endocrinology, Diabetology and Clinical Nutrition
Zurich, Switzerland
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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