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The Role of Renal Progenitors and Polyploid Tubular Cell Response in Glomerular and Tubular Diseases

RecruitingNAAges 1 Month - 17 YearsAllMeyer Children's Hospital IRCCS
NCT06325059 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Renal progenitors are a subset of parietal epithelial cells (PECs) localized at the urinary pole of Bowman's capsule. Experimental models of podocyte damage showed that PECs can potentially regenerate lost podocytes by migrating from Bowman's capsule to the glomerular tuft, acquiring the morphological and functional features of mature podocytes. Podocyte loss and damage, as well as the inability of PECs to replace lost podocytes, lead to glomerular scarring and chronic kidney disease (CKD) progression. In addition, the investigators of the present study and others have recently demonstrated the existence of a specific subpopulation of tubular cells in the human kidney with a high potential for regeneration and resistance to death, thus acting as tubular progenitors. These cells are involved in tubular response to damage during acute kidney injury (AKI) trough endoreplication (polyploidi

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with glomerular diseases undergoing renal biopsy (e.g., rapidly progressive glomerulonephritis, minimal change disease, focal segmental glomerulosclerosis, diabetic nephropathy, lupus nephritis, membranous nephropathy, IgA nephropathy, etc) * Patients with AKI, regardless of the nature of the damage (septal, ischemic, toxic, or unknown). * Signed informed consent form Exclusion Criteria: * Sample insufficient and/or unavailable
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What it tests

  • Study of renal progenitors
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Where

1 site
Meyer Children's Hospital IRCCS
Florence, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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