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Nordic ORgan Preservation Pilot Approach Nonrandomised Single-Arm Trial for Non-Operative Management of Rectal Cancer

RecruitingNAAges 18 Years - anyAllTampere University Hospital
NCT06328361 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this one-arm clinical trial is to implement and study the oncological outcomes of nonoperative management of rectal cancer having complete clinical response to neoadjuvant therapy. The main questions to answer are * if the oncological results of nonoperative management after Nordic practice in chemoradiotherapy indications differ from experiences elsewhere * what is the organ preservation rate * what is the local regrowth rate

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📋 Eligibility rules (as published)
Inclusion Criteria: * Histopathological verification of primary rectal adenocarcinoma * Complete clinical response at response assessment after neoadjuvant therapy * Informed consent to organ preservation study Exclusion Criteria: * Evidence of metastatic disease (fulfilling M-class criteria of TNM) * No neoadjuvant therapy * Inability to understand the information related to harms and benefits
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What it tests

  • Nonoperative surveillance
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Where

13 sites
East Tallinn Central Hospital
Tallinn, Estonia
North Estonia Medical Centre
Tallinn, Estonia
West Tallinn Central Hospital
Tallinn, Estonia
Tartu University Hospital
Tartu, Estonia
Helsinki University Central Hospital
Helsinki, Finland
Jyväskylä Central Hospital
Jyväskylä, Finland
Kuopio University Hospital
Kuopio, Finland
Oulu University Hospital
Oulu, Finland

…and 5 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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